Article
Biosynthesis of mannosylinositolphosphoceramide in Saccharomyces cerevisiae is dependent on genes controlling the flow of secretory vesicles from the endoplasmic reticulum to the Golgi.
The Journal of cell biology - 1 May 1991
Puoti A, Desponds C, Conzelmann A
Abstract excerpt
Saccharomyces cerevisiae contains several abundant phosphoinositol-containing sphingolipids, namely inositolphosphoceramides (IPCs), mannosyl-inositolphosphoceramide (MIPC), which is substituted on the headgroup with an additional mannose, and M(IP)2C, a ceramide substituted with one mannose and two phosphoinositol groups. Using well-defined temperature-sensitive secretion mutants we demonstrate that the...
Topics
- Endoplasmic Reticulum
- Energy Metabolism
- Genes, Fungal
- Glycosphingolipids
- Golgi Apparatus
- Inositol
- Kinetics
- Mannose
- Models, Biological
- Mutation
- Palmitic Acid