Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.

doi:10.1074/jbc.274.48.34294

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.

The Journal of biological chemistry - 26 Nov 1999

Hama H, Schnieders E A, Thorner J, Takemoto J Y, DeWald D B

Abstract excerpt

The SEC14 gene encodes an essential phosphatidylinositol (PtdIns) transfer protein required for formation of Golgi-derived secretory vesicles in yeast. Suppressor mutations that rescue temperature-sensitive sec14 mutants provide an approach for determining the role of Sec14p in secretion. One suppressor, sac1-22, causes accumulation of PtdIns(4)P. SAC1 encodes a phosphatase that can hydrolyze PtdIns(4)P and...

Topics

1-Phosphatidylinositol 4-Kinase
Biological Transport
Carboxypeptidases
Carrier Proteins
Cathepsin A
Gene Expression Regulation, Fungal
Glycoside Hydrolases
Membrane Proteins
Mutation
Phosphatidylinositol Phosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phospholipid Transfer Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Vacuoles

beta-Fructofuranosidase

Source

Open in PubMed

Identifiers

PMID: 10567405
DOI: 10.1074/jbc.274.48.34294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.PMID 10567405Read ↗

SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.Semantic proximity Read ↗

An essential role for a phospholipid transfer protein in yeast Golgi function.Semantic proximity Read ↗

The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi.Semantic proximity Read ↗

A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast.Semantic proximity Read ↗

Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.Semantic proximity Read ↗

Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.Semantic proximity Read ↗

The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum.Semantic proximity Read ↗

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.Semantic proximity Read ↗

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.Semantic proximity Read ↗

Yeast Sec14p Deficient in Phosphatidylinositol Transfer Activity Is Functional In VivoSemantic proximity Read ↗

Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele.Semantic proximity Read ↗

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.