Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999

Barth A I, Stewart D B, Nelson W J

Abstract excerpt

N-terminal mutations in beta-catenin that inhibit beta-catenin degradation are found in primary tumors and cancer cell lines, and increased beta-catenin/T cell factor (TCF)-activated transcription in these cells has been correlated with cancer formation. However, the role of mutant beta-catenin i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Transformation, Neoplastic
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Trans-Activators

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 10220399
DOI: 10.1073/pnas.96.9.4947
PMCID: PMC21797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10220399-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin.PMID 10220399Read ↗

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.Semantic proximity Read ↗

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.Semantic proximity Read ↗

Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest.Semantic proximity Read ↗

SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.Semantic proximity Read ↗

Analysis of the β‐Catenin/T Cell Factor Signaling Pathway in 36 Gastrointestinal and Liver Cancer CellsSemantic proximity Read ↗

p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells.Semantic proximity Read ↗

Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.Semantic proximity Read ↗

Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-Catenin in Colon CancerSemantic proximity Read ↗

Activation of beta-catenin-TCF-mediated transcription by non-receptor tyrosine kinase v-Src.Semantic proximity Read ↗

Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion.Semantic proximity Read ↗

Inhibition of beta-catenin/Tcf signaling by flavonoids.Semantic proximity Read ↗

Threonine 393 of beta-catenin regulates interaction with Axin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.