Article
Activation of beta-catenin-TCF-mediated transcription by non-receptor tyrosine kinase v-Src.
Biochemical and biophysical research communications - 23 Jan 2004
Haraguchi Keiko, Nishida Ayumu, Ishidate Takao, Akiyama Tetsu
Abstract excerpt
Activation of Wnt signaling is an early event in colorectal tumorigenesis, while aberrant activation of non-receptor tyrosine kinase c-Src occurs during tumor progression. Here, we show that v-Src and receptor tyrosine kinase ErbB2 activate beta-catenin-TCF-mediated transcription. The effect of v-Src was abrogated by a dominant-negative mutant of TCF and the tumor suppressor APC. Furthermore, the effect of v-Src...
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