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Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-Catenin in Colon Cancer

17 Sept 2014

Abstract excerpt

During the last decade, mounting evidence has implicated the human neurotropic virus JC virus in the pathology of colon cancer. However, the mechanisms of JC virus-mediated oncogenesis are still not fully determined. One candidate to mediate these effects is the viral early transcriptional product T-Antigen, which has the ability to inactivate cell cycle regulatory proteins such as p53. In medulloblastomas,...

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PMID: 25229241
DOI: 10.1371/journal.pone.0106257

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