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Article

Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging.

Science (New York, N.Y.) - 24 Aug 1990

Johnson T E

Abstract excerpt

A mutation in the age-1 gene of the nematode Caenorhabditis elegans has been shown to result in a 65 percent increase in mean life-span and a 110 percent increase in maximum life-span at 25 degrees. One of the hallmarks of organismic aging and senescent processes is an exponential acceleration of age-specific mortality rate with chronological age. This exponential acceleration is under genetic control: age-1...

Topics

Aging
Animals
Caenorhabditis
Disorders of Sex Development
Life Expectancy
Male
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2392681
DOI: 10.1126/science.2392681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2392681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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