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Understanding alpha-1 antitrypsin deficiency: A review with an allergist's outlook

22 Feb 2017

Abstract excerpt

Alpha-1 antitrypsin (AAT) is the prototypical protease inhibitor from the serine protease inhibitor (serpin) superfamily that protects lung tissue from proteolytic damage by inhibiting neutrophil elastase. Approximately 1 in 2750 to 1 in 4500 individuals have an autosomal codominant condition that leads to a deficiency of circulating AAT. In individuals with AAT deficiency (AATD), AAT is retained in liver cells,...

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PMID: 28234047
DOI: 10.2500/aap.2017.38.4027

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