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Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential

19 Aug 2024

Abstract excerpt

α -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and bronchial epithelial cells. A1AT is encoded by SERPINA1 locus, also known as PI locus, highly polymorphic with at least 100 allelic variants described and...

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PMID: 39224588
DOI: 10.3389/fimmu.2024.1443297

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