Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-1-antitrypsin deficiency: biochemistry and clinical manifestations.

Annals of medicine - 1 Oct 1996

Perlmutter D H

Abstract excerpt

Alpha-1-antitrypsin (alpha 1-AT) deficiency is a well known cause of emphysema in adults. A subgroup of deficient individuals develops liver injury during infancy and childhood. In fact, it is the most common genetic cause of liver disease in children. Although lung injury is due to the decrease in alpha 1-AT function in the lung, allowing uninhibited elastolytic destruction of its connective tissue integrity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to alpha 1-Antitrypsin Deficiency
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Infant

Share to Liver Diseases

Share to Models, Biological

Share to Phenotype

Source

Identifiers

PMID: 8949968
DOI: 10.3109/07853899608999097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-1-antitrypsin deficiency: biochemistry and clinical manifestations.PMID 8949968Read ↗

Historical role of alpha-1-antitrypsin deficiency in respiratory and hepatic complications.Semantic proximity Read ↗

Alpha 1-antitrypsin deficiency and liver disease.Semantic proximity Read ↗

Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions.Semantic proximity Read ↗

Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment.Semantic proximity Read ↗

Alpha-1-antitrypsin deficiency.Semantic proximity Read ↗

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.Semantic proximity Read ↗

Alpha 1-antitrypsin deficiency: an overview.Semantic proximity Read ↗

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging diseaseSemantic proximity Read ↗

Alpha‐1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestationsSemantic proximity Read ↗

Pulmonary manifestations of alpha 1 antitrypsin deficiency.Semantic proximity Read ↗

A Review of α1-Antitrypsin DeficiencySemantic proximity Read ↗

Alpha-1-antitrypsin deficiency: a review; 1963-1975.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.