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Article

Novel variants of SERPIN1A gene: Interplay between alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.

Respiratory medicine - 1 Aug 2016

Bashir Arif, Shah Naveed Nazir, Hazari Younis Mohammad, Habib Mudasir, Bashir Samirul, Hilal Nazia, Banday Mariam, Asrafuzzaman Syed, Fazili Khalid Majid

Abstract excerpt

Alpha1-antitrypsin (AAT) is one of the major circulating anti-protease whose levels in circulation are raised during excessive amount of proteases, especially neutrophil elastase (NE) released during the course of inflammation. Proteolytic attack of NE on peripheral organs, more exclusively on lung parenchyma has severe consequence that may precipitate pulmonary emphysema. Normally, human body has its own...

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Source

Identifiers

PMID: 27492524
DOI: 10.1016/j.rmed.2016.06.005

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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