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Article

Historical role of alpha-1-antitrypsin deficiency in respiratory and hepatic complications.

Gene - 10 Sept 2016

Zuo Li, Pannell Benjamin K, Zhou Tingyang, Chuang Chia-Chen

Abstract excerpt

Alpha-1-antitrypsin (AAT) deficiency is a heritable disease that is commonly associated with complications in the respiratory and hepatic systems. AAT acts as a regulatory enzyme that primarily inhibits neutrophil elastase activity thus protecting tissues from proteolytic damage after inflammation. This paper provides a historical review of the discovery, classification, phenotypic expression, and treatment of...

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Source

Identifiers

PMID: 26768576
DOI: 10.1016/j.gene.2016.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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