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Article

Alpha one antitrypsin deficiency: from gene to treatment.

Respiration; international review of thoracic diseases - 1 Jan 2007

Wood Alice M, Stockley Robert A

Abstract excerpt

Alpha1-antitrypsin deficiency is a genetic disorder which contributes to the development of chronic obstructive pulmonary disease, bronchiectasis, liver cirrhosis and panniculitis. The discovery of alpha1-antitrypsin and its function as an antiprotease led to the protease-antiprotease hypothesis, which goes some way to explaining the pathogenesis of emphysema. This article will review the clinical features of...

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Source

Identifiers

PMID: 17671403
DOI: 10.1159/000105536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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