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Article

Single-cell analysis of glycopeptide resistance gene expression in teicoplanin-resistant mutants of a VanB-type Enterococcus faecalis.

Molecular microbiology - 1 Apr 1999

Baptista M, Rodrigues P, Depardieu F, Courvalin P, Arthur M

Abstract excerpt

The vanB gene cluster confers resistance to vancomycin but not to the related antibiotic teicoplanin, as the VanRB SB two-component regulatory system triggers expression of the glycopeptide resistance genes only in response to vancomycin. The VanRB regulator activates promoters PRB and PYB for transcription of the regulatory (vanRB SB) and resistance (vanYB WHB BXB) genes respectively. The gfpmut1 gene encoding a...

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PMID: 10216856
DOI: 10.1046/j.1365-2958.1999.01308.x

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