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Article

The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor.

Molecular microbiology - 1 Feb 2006

Hutchings Matthew I, Hong Hee-Jeon, Buttner Mark J

Abstract excerpt

We took advantage of the vancomycin-dependent phenotype of Streptomyces coelicolor femX null mutants to isolate a collection of spontaneous, drug-independent femX suppressor mutants that expressed the vancomycin-resistance (van) genes constitutively. All of the suppressor mutations were in vanS but, unexpectedly, many were predicted to be loss-of-function mutations. Confirming this interpretation, a constructed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16420361
DOI: 10.1111/j.1365-2958.2005.04953.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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