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Article

Influence of mutations associated with familial prion-related encephalopathies on biological activity of prion protein peptides.

Annals of neurology - 1 Apr 1999

Forloni G, Angeretti N, Malesani P, Peressini E, Rodriguez Martin T, Della Torre P, Salmona M

Abstract excerpt

In transmissible spongiform encephalopathies (TSEs), an altered form of prion protein (PrP), PrPres, aggregates in amyloid fibrils and accumulates in the brain. Several point mutations of the PrP gene have been associated with the TSEs, so, to investigate how the mutations affect the biological activity of PrP, we analyzed the biological effects and chemicophysical characteristics of the peptide homologous to the...

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PMID: 10211473
DOI: 10.1002/1531-8249(199904)45:4<489::aid-ana10>3.0.co;2-o

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