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Article

Biochemical and structural studies of the prion protein polymorphism.

FEBS letters - 14 Dec 2001

Petchanikow C, Saborio G P, Anderes L, Frossard M J, Olmedo M I, Soto C

Abstract excerpt

A hallmark event in transmissible spongiform encephalopathies is the conversion of the physiological prion protein into the disease-associated isoform. A natural polymorphism at codon 129 of the human prion gene, resulting in either methionine or valine, has profound influence on susceptibility a...

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Identifiers

PMID: 11749972
DOI: 10.1016/s0014-5793(01)03147-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11749972-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Biochemical and structural studies of the prion protein polymorphism.PMID 11749972Read ↗

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Molecular dynamics simulation of local structural models of PrP <sup>Sc</sup> reveals how codon 129 polymorphism affects propagation of PrP <sup>Sc</sup>Semantic proximity Read ↗

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