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Article

Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation.

Chemistry & biology - 1 May 1995

Kazmirski S L, Alonso D O, Cohen F E, Prusiner S B, Daggett V

Abstract excerpt

BACKGROUND: Prion diseases are neurodegenerative disorders that appear to be due to a conformational change, involving the conversion of alpha-helices in the normal, cellular isoform of the prion protein (PrPC) to beta-structure in the infectious scrapie form (PrPSc). One form of Gerstmann-Sträussler-Scheinker syndrome (GSS), an inherited prion disease, is caused by mutation of Ala117 of PrPC to Val. We therefore...

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Source

Identifiers

PMID: 9383432
DOI: 10.1016/1074-5521(95)90049-7

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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