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Article

Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease.

Molecular genetics and metabolism - 1 Jul 2003

Janosíková Bohumila, Pavlíková Markéta, Kocmanová Dora, Vítová Andrea, Veselá Kamila, Krupková Lucie, Kahleová Regina, Krijt Jakub, Kraml Pavel, Hyánek Josef, Zvárová Jana, Andel Michal, Kozich Viktor

Abstract excerpt

It is unresolved whether elevated homocysteine in coronary artery disease (CAD) is the cause of arteriosclerosis or its consequence. In contrast, genetic variants of enzymes that metabolize homocysteine cannot be altered by arteriosclerosis. Consequently, their association with CAD would permit to imply causality. We modeled by regression analysis the effect of 11 variants in the methionine cycle upon CAD...

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Identifiers

PMID: 12855221
DOI: 10.1016/s1096-7192(03)00079-9

Genes

CAD
CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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