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Article

Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.

Biochemistry - 29 Mar 2016

McReynolds Andrea C, Karra Aroon S, Li Yan, Lopez Elias Daniel, Turjanski Adrian G, Dioum Elhadji, Lorenz Kristina, Zaganjor Elma, Stippec Steve, McGlynn Kathleen, Earnest Svetlana, Cobb Melanie H

Abstract excerpt

The mitogen-activated protein kinase ERK2 is able to elicit a wide range of context-specific responses to distinct stimuli, but the mechanisms underlying this versatility remain in question. Some cellular functions of ERK2 are mediated through regulation of gene expression. In addition to phosphorylating numerous transcriptional regulators, ERK2 is known to associate with chromatin and has been shown to bind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26950759
DOI: 10.1021/acs.biochem.6b00096
PMCID: PMC5167559

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