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Article

Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.

The Journal of biological chemistry - 2 Nov 2012

Illert Anna Lena, Zech Michael, Moll Cathrin, Albers Corinna, Kreutmair Stefanie, Peschel Christian, Bassermann Florian, Duyster Justus

Abstract excerpt

NIPA is an F-box-like protein that contributes to the timing of mitotic entry. It targets nuclear cyclin B1 for ubiquitination in interphase, whereas in G(2)/M phase, NIPA is inactivated by phosphorylation to allow for cyclin B1 accumulation, a critical event for proper G(2)/M transition. We recently specified three serine residues of NIPA and demonstrated a sequential phosphorylation at G(2)/M, where initial...

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Identifiers

PMID: 22955283
DOI: 10.1074/jbc.M112.373464
PMCID: PMC3488070

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