Article
Transcriptional cross talk between NF-kappaB and p53.
Molecular and cellular biology - 1 May 1999
Webster G A, Perkins N D
Abstract excerpt
Many cellular stimuli result in the induction of both the tumor suppressor p53 and NF-kappaB. In contrast to activation of p53, which is associated with the induction of apoptosis, stimulation of NF-kappaB has been shown to promote resistance to programmed cell death. These observations suggest that a regulatory mechanism must exist to integrate these opposing outcomes and coordinate this critical cellular...
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