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Article

p300/CBP-dependent and -independent transcriptional interference between NF-kappaB RelA and p53.

Biochemical and biophysical research communications - 7 Jun 2000

Ikeda A, Sun X, Li Y, Zhang Y, Eckner R, Doi T S, Takahashi T, Obata Y, Yoshioka K, Yamamoto K

Abstract excerpt

p53 and NF-kappaB RelA are activated by various genotoxic agents and mutually suppress each other's ability to activate transcription, most likely through competition for transcriptional coactivators such as CBP or p300. However, we found that the inhibition by RelA of p53 transcriptional activity is not completely restored by CBP/p300 overexpression and that a p53 mutant can not suppress RelA activity despite of...

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Source

Identifiers

PMID: 10833421
DOI: 10.1006/bbrc.2000.2786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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