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Article

p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.

The Journal of biological chemistry - 18 Jun 2004

Bohuslav Jan, Chen Lin-Feng, Kwon Hakju, Mu Yajun, Greene Warner C

Abstract excerpt

Apoptosis induced by p53 has been proposed to involve activation of the transcription factor NF-kappaB. Here we describe the novel molecular mechanism through which p53 and DNA-damaging agents activate NF-kappaB. NF-kappaB induction by p53 does not occur through classical activation of the Ikappa...

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Source

Identifiers

PMID: 15073170
DOI: 10.1074/jbc.M313509200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15073170-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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