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Article

Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.

Genesis (New York, N.Y. : 2000) - 1 Apr 2009

van de Hoef Diana L, Hughes James, Livne-Bar Izhar, Garza Dan, Konsolaki Mary, Boulianne Gabrielle L

Abstract excerpt

The gamma-secretase complex is involved in cleaving transmembrane proteins such as Notch and one of the genes targeted in Alzheimer's disease known as amyloid precursor protein (APP). Presenilins function within the catalytic core of gamma-secretase, and mutated forms of presenilins were identified as causative factors in familial Alzheimer's disease. Recent studies show that in addition to Notch and APP,...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Crosses, Genetic

Share to Drosophila melanogaster

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Source

Identifiers

PMID: 19241393
DOI: 10.1002/dvg.20485

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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