Article
Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland.
Journal of medical genetics - 1 Mar 2000
McIlroy S P, Crawford V L, Dynan K B, McGleenon B M, Vahidassr M D, Lawson J T, Passmore A P
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been associated, sometimes controversially, with polymorphisms in a number of genes. Recently the butyrylcholinesterase K variant (BCHE K) allele has been shown to act in synergy with the apolipoprotein E epsilon4 (APOE epsilon4) allele to promote risk for AD. Most subsequent replicative studies have been unable to confirm these...
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