Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.

doi:10.1016/s0304-3940(99)00045-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.

Neuroscience letters - 5 Mar 1999

Middleton D, Mawhinney H, Curran M D, Edwardson J A, Perry R, McKeith I, Morris C, Ince P G, Neill D

Abstract excerpt

The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group. DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers....

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Brain
Exons
Female
Gene Frequency
HLA-A Antigens
HLA-B Antigens
Humans
Male
Matched-Pair Analysis
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 10203251
DOI: 10.1016/s0304-3940(99)00045-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction