Article
Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.
Neuroscience letters - 5 Mar 1999
Middleton D, Mawhinney H, Curran M D, Edwardson J A, Perry R, McKeith I, Morris C, Ince P G, Neill D
Abstract excerpt
The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group. DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers....
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