Article
HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease.
Neuroreport - 14 Apr 1997
Curran M, Middleton D, Edwardson J, Perry R, McKeith I, Morris C, Neill D
Abstract excerpt
Hla-dr antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD....
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