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Association of the HLA-DQB1*02 allele with lower tauopathy in Alzheimer's disease.

Archives of gerontology and geriatrics - 1 Jun 2025

Huda Taha I, Fawcett Timothy J, Green Anthony J, Blanck George

Abstract excerpt

Although many studies have investigated the influence of HLA on the risk of Alzheimer's Disease (AD), there have been inconsistent results. Part of this problem has been attributed to limitations of a clinical assessment in the absence of histopathological confirmation or other quantitative assessments. This study employed a subset of the AD Sequencing Project, representing 2663 cases with histopathological...

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PMID: 40068480
DOI: 10.1016/j.archger.2025.105802

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