Article
No association between the HLA-A2 allele and Alzheimer disease.
Neurogenetics - 1 Sept 1999
Small G W, Scott W K, Komo S, Yamaoka L H, Farrer L A, Auerbach S H, Saunders A M, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
The apolipoprotein E (APOE)-4 allele is a major risk factor for late-onset Alzheimer disease (AD), but it does not account for all the genetic variation in late-onset AD; thus, other genetic markers must be examined. Previous studies suggest an HLA-A2 allele association with risk and earlier onset age of AD. Because these effects may be additive to those of APOE-4, we studied HLA-A2 and APOE-4 frequencies in AD...
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