Article
Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 1999
Friedl-Hajek R, Spangfort M D, Schou C, Breiteneder H, Yssel H, Joost van Neerven R J
Abstract excerpt
BACKGROUND: Allergen-specific CD4+ T cells play an important regulatory role in atopic allergy. OBJECTIVE: To investigate the human leucocyte antigen (HLA) restriction and T-cell receptor (TCR) usage of allergen-specific T-cell clones (TCCs) that react with defined epitopes of Bet v 1, the major birch pollen allergen. METHODS: Five Bet v 1-specific TCCs derived from two birch pollen-allergic individuals and...
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