Article
Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01.
The Journal of allergy and clinical immunology - 1 Feb 2005
Jahn-Schmid Beatrice, Fischer Gottfried F, Bohle Barbara, Faé Ingrid, Gadermaier Gabriele, Dedic Azra, Ferreira Fatima, Ebner Christof
Abstract excerpt
BACKGROUND: Mugwort pollen allergens are the main cause of pollinosis in late summer in Europe. Ninety-five percent of patients allergic to mugwort are sensitized to the major allergen Art v 1. In contrast to other common pollen allergens that contain multiple T-cell epitopes, Art v 1 contains only 1 immunodominant T-cell epitope (Art v 1 25-36 ). OBJECTIVE: To characterize the minimal epitope of Art v 1 25-36...
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