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Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells

13 Apr 1999

Abstract excerpt

A PCR strategy is described for global amplification of DNA from a single eukaryotic cell that enables the comprehensive analysis of the whole genome. By comparative genomic hybridization, not only gross DNA copy number variations, such as monosomic X and trisomic 21 in single male cells and cells from Down's syndrome patients, respectively, but multiple deletions and amplifications characteristic for human tumor...

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PMID: 10200290
DOI: 10.1073/pnas.96.8.4494

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