Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation

Abstract excerpt

Molecular genetic analysis of isolated single cells and other minute DNA samples is limited because there is insufficient DNA to perform more than one independent PCR amplification. One solution to this problem is to first amplify the entire genome, thus providing enough DNA for numerous subsequent PCRs. In this study we have investigated four different methods of whole genome amplification performed on single...

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• Share to Chromosomal and Genetic Variations
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