Article
Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations.
Immunology - 1 Feb 1995
Southern C, Wilkinson P C, Thorp K M, Henderson L K, Nemec M, Matthews N
Abstract excerpt
Circulating lymphocytes are rounded, non-motile cells which on contact with cytokines, specialized or activated endothelium, acquire a constantly shape-changing, polarized morphology which enables migration into appropriate sites. The biochemical mechanisms which regulate this switch are not unde...
Topics
- Alkaloids
- B-Lymphocytes
- Blotting, Western
- Cell Line
- Cell Movement
- Cells, Cultured
- Enzyme Activation
- Humans
- Indoles
- Lymphocytes
- Maleimides
- Marine Toxins
- Oxazoles
- Phenotype
- Phosphoprotein Phosphatases
- Protein Kinase C
- Staurosporine
- T-Lymphocytes