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Article

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines.

Neuron - 1 Mar 1999

Beck C, Wollmuth L P, Seeburg P H, Sakmann B, Kuner T

Abstract excerpt

In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved. Using the substituted cysteine accessibility method (SCAM), we identified channel-lining residues of the NR1 subunit in the region preceding M1 (preM1), the C-terminal part of M3 (M3C), and the N-terminal part of M4...

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Identifiers

PMID: 10197535
DOI: 10.1016/s0896-6273(00)80710-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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