Article

Subconductance states in NMDA receptor variants are Ca2+ impermeable and act at the M2 loop

2026-07-07

Abstract excerpt

<title>Abstract</title> <p>A variety of de novo disease-associated variants are found in NMDA receptors (NMDARs), which carry out critical roles at synapses including mediating a Ca2+ influx. In the central permeation pathway, a vestibule is positioned between the external M3 gate and the M2 pore loop. A variant in the obligatory GluN1 subunit, Met641Ile, reduces Ca2+ permeability, but the mechanism of action is...

Identifiers and source

Literature Corpus work: 1c8b8ae4-e492-56b3-9f9c-87e5acbaefa8
DOI: 10.21203/rs.3.rs-10155714/v1

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