Article
Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR).
European journal of human genetics : EJHG - 1 Jan 2000
Heijmans B T, Gussekloo J, Kluft C, Droog S, Lagaay A M, Knook D L, Westendorp R G, Slagboom E P
Abstract excerpt
An elevated level of homocysteine in plasma is associated with the occurrence of cardiovascular disease. A common ala-to-val mutation in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an elevated level of plasma homocysteine. We studied the possible detrimental effects of the MTHFR mutation on mortality. Within a population-based study in the city of Leiden, the Netherlands, we first...
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