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Article

Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden.

JAMA network open - 1 May 2020

Calderón-Larrañaga Amaia, Saadeh Marguerita, Hooshmand Babak, Refsum Helga, Smith A David, Marengoni Alessandra, Vetrano Davide L

Abstract excerpt

Importance: Strong evidence links high total serum homocysteine (tHcy) and low methionine (Met) levels with higher risk of ischemic disease, but other cardiovascular (CV) diseases may also be associated with their pleiotropic effects. Objectives: To investigate the association of serum concentrations of tHcy and Met with the rate of CV multimorbidity development in older adults and to explore the role of...

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Identifiers

PMID: 32432712
DOI: 10.1001/jamanetworkopen.2020.5316
PMCID: PMC7240355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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