Article
Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates.
Journal of human virology - 1 Jan 2000
Gartner S, McDonald R A, Hunter E A, Bouwman F, Liu Y, Popovic M
Abstract excerpt
OBJECTIVE: We sought to identify genetic determinants within human immunodeficiency virus type 1 (HIV-1) gp120 that differentiate viral species in brain from those in lymphocytes. STUDY DESIGN/METHODS: Polymerase chain reaction (PCR) was used to amplify gp120 genes from paired brain and T-cell isolates from two infants and two adults with dementia. Amplimers were molecularly cloned and sequenced. RESULTS: The...
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