Article
Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients.
Journal of virology - 1 Nov 1998
Power C, McArthur J C, Nath A, Wehrly K, Mayne M, Nishio J, Langelier T, Johnson R T, Chesebro B
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) infection of the brain results in viral replication primarily in macrophages and microglia. Despite frequent detection of viral genome and proteins in the brains of AIDS patients with and without HIV dementia, only 20% of AIDS patients become demented. To investigate the role of viral envelope gene variation in the occurrence of dementia, we examined regions of...
Topics
- AIDS Dementia Complex
- Amino Acid Sequence
- Brain
- Cell Death
- Cells, Cultured
- Gene Products, env
- Genes, env
- Genetic Variation
- HIV-1
- HeLa Cells
- Humans
- Macrophages
- Molecular Sequence Data
- Neurons