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Article

HIV-1 V3 domain variation in brain and spleen of children with AIDS: tissue-specific evolution within host-determined quasispecies.

Virology - 1 Feb 1991

Epstein L G, Kuiken C, Blumberg B M, Hartman S, Sharer L R, Clement M, Goudsmit J

Abstract excerpt

DNA coding for the principal neutralization epitope of HIV-1 (the V3 domain of the envelope glycoprotein gp120) was amplified by polymerase chain reaction from postmortem brain and spleen tissue of three perinatally infected children who died of AIDS with progressive encephalopathy. Sequences obtained directly (without cloning) from this DNA were compared with sequences of 52 molecular clones made from this DNA....

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
Biological Evolution
Brain
Child
DNA Probes
DNA, Viral
Genetic Variation
HIV Envelope Protein gp120
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Oligonucleotide Probes

Polymerase Chain Reaction

Spleen

Source

Identifiers

PMID: 1989385
DOI: 10.1016/0042-6822(91)90072-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1989385-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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HIV-1 V3 domain variation in brain and spleen of children with AIDS: tissue-specific evolution within host-determined quasispecies.PMID 1989385Read ↗

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