Article
Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD.
Biochemical and biophysical research communications - 20 Jul 2007
Vibhuti Arpana, Arif Ehtesham, Deepak Desh, Singh Bhawani, Qadar Pasha M A
Abstract excerpt
The genetic susceptibility to COPD might depend on variations in detoxification enzymes that activate and detoxify cigarette smoke products, which otherwise generate oxidative stress causing pathogenesis. In a case-control study of 202 COPD patients and 136 normals, we examined the association of polymorphisms I105V, A114V of GSTP1 and Y113H, H139R of mEPHX individually or in combination with disease and their...
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