Article
Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease.
Chinese medical journal - 1 May 2004
Xiao Dan, Wang Chen, Du Min-jie, Pang Bao-sen, Zhang Hong-yu, Xiao Bai, Liu Jing-zhong, Weng Xin-zhi, Su Li, Christiani David C
Abstract excerpt
BACKGROUND: Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only 10% - 20% of chronic heavy cigarette smokers develop symptomatic disease. COPD is most likely the result of complex interactions between environmental and genetic factors. Genetic susceptibility to COPD might depend on the variations in enzyme activities that detoxify cigarette smoke products,...
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