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Article

The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype.

International journal of experimental pathology - 1 Oct 1998

Boot-Handford R P, Michaelidis T M, Hillarby M C, Zambelli A, Denton J, Hoyland J A, Freemont A J, Grant M E, Wallis G A

Abstract excerpt

Histological examination of long bones from 1-day-old bcl-2 knockout and age-matched control mice revealed no obvious differences in length of bone, growth plate architecture or stage of endochondral ossification. In 35-day-old bcl-2 knockout mice that are growth retarded or 'dwarfed'. the proliferative zone of the growth plate appeared slightly thinner and the secondary centres of ossification less well...

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Identifiers

PMID: 10193316
DOI: 10.1046/j.1365-2613.1998.790411.x
PMCID: PMC3220196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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