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Article

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice.

Cell death & disease - 13 Mar 2020

Ke Francine, Lancaster Graeme I, Grabow Stephanie, Murphy Andrew J, Strasser Andreas

Abstract excerpt

The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins have also been identified. In the process of studying mice lacking single alleles of Mcl-1...

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Identifiers

PMID: 32170090
DOI: 10.1038/s41419-020-2376-5
PMCID: PMC7070015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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