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Article

IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukaemia.

British journal of haematology - 1 Apr 2006

Bagnara Davide, Callea Vincenzo, Stelitano Caterina, Morabito Fortunato, Fabris Sonia, Neri Antonino, Zanardi Sabrina, Ghiotto Fabio, Ciccone Ermanno, Grossi Carlo Enrico, Fais Franco

Abstract excerpt

Intraclonal diversification of immunoglobulin (Ig) variable (V) genes was evaluated in leukaemic cells from a B-cell chronic lymphocytic leukaemia (B-CLL) case over a 2-year period at four time points. Intraclonal heterogeneity was analysed by sequencing 305 molecular clones derived from polymerase chain reaction amplification of B-CLL cell IgV heavy (H) and light (C) chain gene rearrangements. Sequences were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphocyte Activation

Share to Receptors, Antigen, B-Cell

Share to Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 16512828
DOI: 10.1111/j.1365-2141.2005.05974.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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