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Article

In situ detection of mutated hepatitis B virus in microdissected, formalin-fixed liver tissues from patients with chronic hepatitis B.

Journal of hepatology - 1 Mar 1999

Kojima N, Horiike N, Michitaka K, Onji M

Abstract excerpt

BACKGROUND/AIMS: Hepatitis B virus (HBV) quasispecies have been detected in patients with chronic hepatitis B. In order to elucidate the relationship between HBV mutation and liver cell necrosis in situ, we analyzed sublobule-sized specimens microdissected from formalin-fixed paraffin-embedded liver biopsy tissues taken from patients with chronic hepatitis B. METHODS: The subjects were 20 patients with chronic...

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Identifiers

PMID: 10190715
DOI: 10.1016/s0168-8278(99)80091-9

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