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Article

Detection of widespread hepatocyte infection in chronic hepatitis C

1 Aug 1998

Abstract excerpt

The controversial question of the extent of hepatocyte infection in chronic hepatitis C was re-examined in both chimpanzees and humans using a newly modified in situ hybridization (ISH) method for detecting hepatitis C virus (HCV) RNA. The specificity of the methodology for distinguishing positive- and negative-strand synthetic HCV RNA was at least six magnitudes greater than the reverse-transcription polymerase...

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Identifiers

PMID: 9696027
DOI: 10.1002/hep.510280240

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