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Article

Mainly unmutated V(H) genes rearranged in B cells forming germinal centers in a cutaneous pleomorphic T-cell lymphoma.

Journal of cutaneous pathology - 1 Jan 1999

Golembowski S, Gellrich S, Lorenz P, Rutz S, Audring H, Sterry W, Jahn S

Abstract excerpt

B cells in skin lesions of a pleomorphic cutaneous T-cell lymphoma with reactive germinal center hyperplasia were analyzed for their immunoglobulin V(H)DJ(H) gene rearrangements by micromanipulation and single cell polymerase chain reaction (PCR) analysis. In B lymphocytes located in germinal center-like structures, we found in 11/16 different V(H)DJ(H) rearrangements completely unmutated VH genes, suggesting...

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Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Germinal Center

Share to Immunoglobulin Variable Region

Share to Ki-1 Antigen

Share to Lymphoma, T-Cell, Cutaneous

Share to Skin Neoplasms

Source

Identifiers

PMID: 10189248
DOI: 10.1111/j.1600-0560.1999.tb01783.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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