Article
Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells.
The New England journal of medicine - 14 Aug 1997
Marafioti T, Hummel M, Anagnostopoulos I, Foss H D, Falini B, Delsol G, Isaacson P G, Pileri S, Stein H
Abstract excerpt
BACKGROUND: The atypical cells of nodular lymphocyte-predominant Hodgkin's disease, designated lymphocytic and histiocytic (L&H) cells, have a B-cell phenotype. To clarify the clonality of these cells, we studied rearranged immunoglobulin genes for the variable region of the heavy chain (V[H] gen...
Topics
- B-Lymphocytes
- Clone Cells
- Genes, Immunoglobulin
- Hodgkin Disease
- Humans
- Immunoglobulin Heavy Chains
- Mutation